Advt No.15/2021 : Appointment of a Graduate Trainee in Computational Structural Biology in the laboratory of Dr Shruthi Vishwanath
Essential Qualification and Experience required:
Bachelor or Master's in any branch of science or engineering.
One (1) year project experience that involves programming in computational biology.
Programming experience in Python/C++.
Comfortable working in Linux environment.
Ability to read and synthesize literature in molecular and cell biology.
Computational modeling of 3D structures of large macromolecular assemblies
Three-dimensional structures of large protein assemblies help us understand the mechanistic details of biological processes in the cell. They provide insight into how these molecular machines function, how they are assembled, how they evolved, and how they are regulated. However, such structures are difficult to obtain using any single experimental method. We use computational modeling to determine these structures by combining a variety of experimental data, physical theories, and statistical inference.
Opportunities exist in our group to work on several such assemblies. Three broad areas include (a) assemblies involved in regulating gene expression, including chromatin remodelers (b) assemblies at cell-cell junctions, and (c) cellular machineries involved in cell division such as centriolar and centrosomal protein complexes.
There is a possibility to experimentally validate the in-silico model in our collaborators’ labs.
There are also opportunities to work on improving the modeling methods, using algorithms from statistical inference, for trainees from a more quantitative background.
Number of positions: 2
Minimum % of marks: 75%
Age limit: 40
Salary offered: 25,000 (without CSIR/GATE/equivalent qualification),31000 + 24% HRA (with CSIR/GATE/equivalent qualification)